"We surveyed vital status and cancer incidence, and found a strong trend for a decrease in prostate cancer risk as the number of sons increased," said Susan Harlap, MD, professor of clinical Epidemiology at the Mailman School of Public Health, and the leader of the research team. "We anticipate that this finding will have a significant impact on the direction of research in this field going forward." Overall, there was a 40% increase in prostate cancer in men lacking sons.
The offspring's sex depends on whether it receives an X or a Y chromosome from the father. A man with a damaged Y chromosome will be less likely to have sons and those with a damaged X chromosome may be unable to sire daughters. "Our findings suggest that the biological significance of lack of sons -- whatever it is that leads to increased risk of prostate cancer - becomes increasingly important as family size increases," observes Dr. Harlap. "Overall, our findings are consistent with hypotheses that tie Y chromosome loci to prostate cancer, although other explanations cannot be excluded," implies Dr. Harlap.
The researchers also looked at men lacking daughters. For example, in men with exactly two offspring, those with no daughters had an 11% increase in the incidence of prostate cancer, and those with no sons had a 47% increase, compared with men who had one son and one daughter. "The increased risk of prostate cancer in men with no daughters is probably due to chance," says Dr. Harlap, "but it might indicate a problem with a gene on the X-chromosome."
Via Health & Longevity blog
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